Lymphocyte Subpopulations in Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) is a non-neoplastic inflammatory lesion of gingival tissues. This study aims to evaluate and compare lymphocyte subpopulations in PGCG tissues and adjacent healthy gingival tissues obtained from the same individuals. A total of 28 systemically healthy, non-smoking patients diagnosed with PGCG are included in this study. Biopsy samples are collected during surgical excision of PGCG lesions, and corresponding healthy gingival tissues are obtained from the same patients. Immunohistochemical analysis is performed to assess lymphocyte subpopulations, including CD3, CD4, CD8, CD20, and CD79a. The proportions of these cells are compared between diseased and healthy tissues.

NCT Number	NCT07551310
Lead Sponsor	Ataturk University
Conditions	Peripheral Giant Cell Granuloma, Gingival Lesions, Gingival Enlargement
Enrollment	28 participants
Start Date	2026-01-01
Primary Completion	2026-03-01 (estimated)
Study Completion	2026-03-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-18