Efficacy and Safety of Etoricoxib+Diacerein in Osteoarthritis.

The goal of this clinical trial is to learn if fixed-dose combination etoricoxib 90 mg + diacerein 50 mg capsule works to treat knee/hip osteoarthritis-associated pain in adults. It will also learn about the safety of the drug. The main questions it aims to answer are: Does etoricoxib+diacerein reduce pain intensity as per WOMAC scale after 60 days? What medical problems do participants have when taking etoricoxib 90 mg+diacerein 50 mg capsule for 60 days? Researchers will compare the test drug etoricoxib 90 mg+diacerein 50 mg capsule to an active comparator (meloxicam 15 mg + diacereina 50 mg) to see if drug ABC works to treat pain in patients with osteoarthritis. Participants will: Take drug the test or comparator drugs every day for 60 days. Visit the clinic once a month for health and outcomes follow-up. Keep a diary of their symptoms, pain intensity, WOMAC scale, adverse events, rescue medication use, other used drugs, and treatment adherence.

NCT Number	NCT07549386
Lead Sponsor	Laboratorios Liomont Collaborators: EPIC Research CRO
Conditions	Pain Management, Osteoarthritis
Enrollment	123 participants
Start Date	2024-05-24
Primary Completion	2025-03-27 (estimated)
Study Completion	2025-10-15 (estimated)
Updated on ClinicalTrials.gov	2026-04-29