Clinical Trial

taVNS During Multi-site HRV Measurement: Reliability & Agreement Study

Study acronym: taVNS-HRV
Enrolling by Invitation
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Summary
This study examines the reliability and agreement of autonomic nervous system measurements obtained from different anatomical sites during transcutaneous auricular vagus nerve stimulation (taVNS). taVNS is a non-invasive electrical stimulation delivered to the ear using a small stimulator. Healthy volunteers aged 18-40 years will participate in one laboratory session. Heart rate and heart rate variability will be recorded from the chest (reference), finger, and arm. Blood pressure and pulse will also be measured. Data will be collected in three standardized periods: T0 (5-minute resting baseline), T1 (10 minutes during taVNS), and T2 (5-minute recovery). The main goal is to determine how closely finger- and arm-based measurements match the chest reference and how consistent these measurements are across the study periods. Participation is voluntary, and participants may withdraw at any time. Expected risks are minimal and may include temporary tingling or mild discomfort at the ear and, rarely, lightheadedness. No direct medical benefit is expected, but the findings may help improve how autonomic responses are monitored during taVNS in future research.
Trial Details
NCT Number NCT07548723
Lead Sponsor SEFA HAKTAN HATIK
Conditions Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV), Blood Pressure Monitoring, Transcutaneous Electric Nerve Stimulation, Photoplethysmography
Enrollment 1 participants
Start Date 2023-03-20
Primary Completion 2026-04-20 (estimated)
Study Completion 2026-05-05 (estimated)
Updated on ClinicalTrials.gov 2026-04-23