Clinical Trial

Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic and Cognitive Performance in Recreationally Active Males

Completed
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Summary
This randomized, double-blind, four-period crossover trial investigates the acute effects of creatine monohydrate, L-arginine, and their combined administration on anaerobic performance, jump performance, and cognitive reaction time in recreationally active adult males. Eighteen healthy male participants complete four experimental conditions in randomized order: placebo, creatine, L-arginine, and creatine plus L-arginine, with at least 72 hours between sessions. Sixty minutes after supplementation, participants perform the Stroop Color-Word Test, countermovement jump test, and Running-Based Anaerobic Sprint Test. Primary outcomes include peak power, average power, countermovement jump height, and incongruent Stroop reaction time. The study aims to determine whether acute co-supplementation produces greater ergogenic and cognitive benefits than either supplement alone or placebo.
Trial Details
NCT Number NCT07548541
Lead Sponsor Inonu University
Collaborators: Princess Nourah Bint Abdulrahman University
Conditions Anaerobic Performance, Cognitive Performance, Healthy Volunteers
Enrollment 18 participants
Start Date 2025-04-01
Primary Completion 2025-05-15 (estimated)
Study Completion 2025-05-16 (estimated)
Updated on ClinicalTrials.gov 2026-04-23