Clinical Trial

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Study acronym: STRIDE-PAIN
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery? 2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.
Trial Details
NCT Number NCT07548385
Lead Sponsor Icahn School of Medicine at Mount Sinai
Conditions Total Knee Replacement Surgery, Post-operative Pain
Enrollment 235 participants
Start Date 2026-04
Primary Completion 2027-02-23 (estimated)
Study Completion 2027-02-23 (estimated)
Updated on ClinicalTrials.gov 2026-04-23