This clinical study aimed to compare the effectiveness of Post-Facilitation Stretch (PFS) and Active Release Technique (ART) on pain, disability, quality of life, and range of motion of hip internal and external rotation in female patients with piriformis syndrome. After recruitment, participants were randomly allocated into two groups using the chit-box method, either in group A Post-Facilitation Stretch, and group B Active Release Technique. Clinical outcomes including pain, disability, quality of life, and hip range of motion (abduction and internal rotation) were assessed at baseline, during the third week of treatment, and at the sixth-week follow-up from the National Institute of Rehabilitation and Medicine (NIRM) Hospital.