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Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery

Study acronym: PROPEEP
StatusNot Yet Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 11, 2026 (before its estimated September 2, 2026 completion). Its status may not reflect the trial's current state.
Trial flagged as At Risk
Primary completion moved at least 2 months later Jul 2, 2026 → Sep 2, 2026
See other at-risk trials from Harran University

Record History

  1. Start date: May 1, 2026 to Aug 15, 2026
    • Primary completion pushed from Jul 2, 2026 to Sep 2, 2026
    • Study completion pushed from Sep 3, 2026 to Oct 3, 2026
    v3
  2. Study Status, Eligibilityv2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.
Trial Details
NCT Number NCT07545733
Lead Sponsor Harran University
Conditions
(from sponsor)		 Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
Related terms Intervertebral Disc Displacement
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov