Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery

This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.

NCT Number	NCT07545733
Lead Sponsor	Harran University
Conditions	Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
Enrollment	60 participants
Start Date	2026-08-15
Primary Completion	2026-09-02 (estimated)
Study Completion	2026-10-03 (estimated)
Updated on ClinicalTrials.gov	2026-08-11