Autoimmune Hyperthyroidism in Prepubertal Children

The investigators propose a multicenter retrospective study to assess clinical, biochemical, and auxological characteristics at diagnosis and during follow-up in a cohort of Caucasian pediatric patients diagnosed with autoimmune hyperthyroidism before puberty. These prepubertal patients will be compared with a control group of post-pubertal patients with Graves' disease. This study aims to enhance the understanding of autoimmune hyperthyroidism in prepubertal patients by providing a detailed evaluation of disease onset, therapeutic response, and growth-related outcomes. The inclusion of a carefully matched post-pubertal control group will allow for robust comparative analysis and identification of age-dependent clinical patterns and prognostic indicators, ultimately supporting more tailored and effective management strategies in pediatric populations at this particular age.

NCT Number	NCT07544290
Lead Sponsor	IRCCS Ospedale San Raffaele Collaborators: University of Campania Luigi Vanvitelli, University of Genova, S. Anna Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Azienda Ospedaliera Universitaria Integrata Verona, Fondazione IRCCS San Gerardo dei Tintori, Azienda Ospedaliera Universitaria Policlinico "G. Martino", Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria, Università di Torino, Torino, Federico II University, Buzzi Children's Hospital
Conditions	Autoimmune Hyperthyroidism, Children
Enrollment	100 participants
Start Date	2026-01-01
Primary Completion	2026-01-01 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-22