Cohort of Repeat Donor Experiences (CORE) Study

The Plasma Protein Therapeutics Association (PPTA) sponsors the Cohort of Repeat Donor Experiences (CORE) Study. This is a prospective, observational cohort study that will follow Source Plasma donors for up to 2 years during the main study (anticipated to begin in summer 2026) and up to 3 months during the pilot launching in mid-March 2026. This study aims to confirm a lack of negative health effects Source Plasma donors may experience as a result of frequent plasmapheresis. The study will use data obtained through self-report surveys for the duration of the study along with periodic whole blood sample collections to test for CRP, ferritin, and IgG.

NCT Number	NCT07543965
Lead Sponsor	Westat Collaborators: Plasma Protein Therapeutics Association
Conditions	Health Effects (Ferritin Levels, CRP Levels, iGg Levels, Self-reported Health)
Enrollment	2,090 participants
Start Date	2026-04-06
Primary Completion	2028-07-01 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-22