Comparison of Propofol and Propofol-Ketamine Anesthesia on Optic Nerve Sheath Diameter in Endovascular Cerebral Aneurysm Procedures

This study aimed to compare the effects of propofol-based anesthesia and propofol-ketamine anesthesia on optic nerve sheath diameter (ONSD) in patients undergoing elective endovascular treatment of unruptured intracranial aneurysms. ONSD, measured using ultrasonography, is a non-invasive surrogate marker of intracranial pressure. In addition, intraoperative hemodynamic parameters, cerebral oxygenation, and anesthetic requirements were evaluated to assess the safety and physiological impact of the two anesthesia techniques.

NCT Number	NCT07542015
Lead Sponsor	Ankara City Hospital Bilkent Collaborators: Uludag University
Conditions	Unruptured Intracranial Aneurysm, Cerebral Aneurysm Unruptured, Cerebral Aneurysms
Enrollment	46 participants
Start Date	2025-06-15
Primary Completion	2025-12-20 (estimated)
Study Completion	2026-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-21