Effects of Berberine on Cardiometabolic Outcomes

Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. It has been postulated that Berberine may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention.

NCT Number	NCT07541898
Lead Sponsor	University of Central Lancashire Collaborators: DoNotAge.org
Conditions	Cardiometabolic Syndrome
Enrollment	40 participants
Start Date	2026-07-01
Primary Completion	2028-08-01 (estimated)
Study Completion	2029-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-21