Clinical Trial

Efficacy of Chlorhexidine and Morus Nigra Mouthwashes After Periodontal Treatment

Active, Not Recruiting
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Record status
This record was last updated April 20, 2026 (before its estimated June 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study aims to evaluate and compare the clinical, biochemical, and microbiological effects of chlorhexidine and Morus nigra (blackberry) mouthwashes used as an adjunct to non-surgical periodontal treatment (scaling and root planing - SRP) in patients with periodontal diseases. The participants will be divided into three groups: a control group receiving only SRP, a group receiving SRP combined with chlorhexidine mouthwash, and a group receiving SRP combined with Morus nigra mouthwash. Clinical periodontal parameters, gingival crevicular fluid levels of inflammatory markers (including TNF-a, IL-1b, and IL-10), and subgingival plaque microbiological profiles (such as red complex bacteria and Fusobacterium) will be evaluated at baseline, 1 month, and 3 months after the treatment.
Trial Details
NCT Number NCT07540624
Lead Sponsor Inonu University
Conditions Periodontitis, Periodontal Disease
Enrollment 48 participants
Start Date 2025-05-08
Primary Completion 2026-06-01 (estimated)
Study Completion 2026-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-20