Clinical Trial

CAIX PET/ CT Guided Radiation Therapy in CcRCC.

Study acronym: COSTAR-002
Recruiting
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Summary
This is a prospective, single-arm study in adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and undergo dual PET/CT imaging (FDG PET/CT and a CAIX-targeted PET/CT) to map disease sites. When feasible, PET/CT-visible lesions will be treated with image-guided stereotactic ablative radiotherapy (SABR). Patients will be followed to evaluate progression-free survival, local control of treated lesions, and treatment-related adverse events (planned enrollment: \~70).
Trial Details
NCT Number NCT07540260
Lead Sponsor Peking University First Hospital
Conditions Radiation Therapy, Metastatic Renal Cancer, Recurrent Renal Cell Cancer
Enrollment 70 participants
Start Date 2025-11-01
Primary Completion 2030-12-31 (estimated)
Study Completion 2030-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-20