Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study

This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.

NCT Number	NCT07539883
Lead Sponsor	Seoul National University Bundang Hospital Collaborators: Vantive Health LLC
Conditions	Septic Shock, Multiorgan Failure, Sepsis
Enrollment	360 participants
Start Date	2026-01-22
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-20