The Comparison Between M-E-BCS and C-O-BCS.

This study is a multicenter, open-label, randomized controlled trial. The study aims to evaluate differences in operative efficiency (e.g., operative time), economic effect, surgical safety (e.g., surgical complication rates), postoperative aesthetics (e.g., BREAST-Q scores, Harris scores, SCAR-Q scores and Ueda scores), and oncological safety (e.g., margin status, no local recurrence survival) between patients undergoing M-E-BCS and patients undergoing C-O-BCS.

NCT Number	NCT07539545
Lead Sponsor	Du Zhenggui Collaborators: West China Fourth Hospital, West China Second University Hospital, Fourth People's Hospital of Sichuan Province, Taiyuan Central Hospital of Shanxi Medical University, Chengdu Second people's hospital, Suzhou Municipal Hospital
Conditions	Breast Cancer
Enrollment	1,366 participants
Start Date	2026-04-01
Primary Completion	2032-12-01 (estimated)
Study Completion	2032-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-20