Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth

This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices. Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth. In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period. The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.

NCT Number	NCT07538921
Lead Sponsor	Cairo University
Conditions	Concentrated Growth Factor
Enrollment	7 participants
Start Date	2026-06
Primary Completion	2027-06 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-07