MCE Molecular Imaging for ICI Myocarditis

Inflammation of the heart (myocarditis) is a serious condition that can cause heart failure, abnormal heart rhythms, cardiac arrest, and death. A new class of medications used for cancer called immune checkpoint inhibitors (ICI) work by increasing the body's inflammmation response, but can have a side effect of causing inflammation of the heart (ICI myocarditis). Rapid diagnosis of this condition is key to reversing it. The purpose of this study is to determine whether ICI myocarditis can be diagnosed using a new form of ultrasound imaging of the heart (echocardiography) that uses a contrast agent that is targeted to inflammation (Sonazoid).

NCT Number	NCT07538544
Lead Sponsor	University of Virginia Collaborators: GE Healthcare
Conditions	Immune Checkpoint Inhibitor Myocarditis
Enrollment	30 participants
Start Date	2026-09-15
Primary Completion	2030-06-30 (estimated)
Study Completion	2030-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-12