Caries Removal Methods and Microbiome Changes

Dental caries management approaches may influence not only tissue removal but also the microbial composition within the cavity. However, clinical evidence on how different caries removal methods affect the oral microbiome remains limited. This study aims to evaluate the effects of selective and non-selective caries removal methods on the diversity and composition of the oral microbiome using 16S rRNA gene sequencing. The findings are expected to help identify biologically compatible treatment approaches that effectively reduce pathogenic microorganisms.

NCT Number	NCT07538089
Lead Sponsor	Nuh Naci Yazgan University
Conditions	Caries, Dental
Enrollment	48 participants
Start Date	2026-02-26
Primary Completion	2026-05 (estimated)
Study Completion	2026-08 (estimated)
Updated on ClinicalTrials.gov	2026-04-20