Clinical Trial

EEG-TMS for Postoperative Delirium After Cardiac Surgery

Study acronym: RECOVER-C
Not Yet Recruiting
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Summary
This is a prospective, single-center, randomized, double-blind, sham-controlled trial evaluating the safety and efficacy of transcranial magnetic stimulation (TMS) for the treatment of postoperative delirium in patients undergoing cardiac surgery with extracorporeal circulation. Eligible patients aged 50 years or older who develop delirium after surgery, as assessed by the CAM-ICU, will be randomized to receive either active TMS or sham stimulation. The intervention consists of three daily cycles of intermittent and continuous theta burst stimulation over five days. The primary outcome is the duration of delirium within the five-day intervention period. Secondary outcomes include delirium severity, time to successful discharge, and survival at 30 and 90 days. A total of 144 participants will be enrolled.
Trial Details
NCT Number NCT07537725
Lead Sponsor RenJi Hospital
Conditions Delirium
Enrollment 144 participants
Start Date 2026-04-27
Primary Completion 2026-12-30 (estimated)
Study Completion 2027-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-17