Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.

NCT Number	NCT07536204
Lead Sponsor	University of Chile
Conditions	Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases, Periodontal Attachment Loss
Enrollment	30 participants
Start Date	2023-06-01
Primary Completion	2027-03-31 (estimated)
Study Completion	2027-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-17