The Voided Urinary, Perineal, and Faecal Microbiota Among Children and Adolescents - the PpUF-study.

The aim of this study is to investigate whether the voided urinary, perineal/preputial, and the fecal microbiota are different between children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the study aims to investigate if the microbiota is different according to the severity of DUI and if the microbiota is changed throughout treatment of DUI. A follow-up study will as well be performed on healthy children to investigate how the microbiota evolves with increasing age and pubertal stage. Children with OAB and DUI will be recruited from involved pediatric departments, and specimen in the form of urine, perineal/preputial swabs, and feces will be collected according to the protocol.

NCT Number	NCT07535619
Lead Sponsor	Aalborg University Hospital Collaborators: Aarhus University Hospital, Regional Hospital West Jutland, Regionshospital Nordjylland
Conditions	Urinary Incontinence, Daytime Wetting, Urination Disorders, Urologic Diseases, Lower Urinary Tract Symptoms, Urological Manifestations, Elimination Disorders, Behavioral Symptoms
Enrollment	110 participants
Start Date	2022-12-14
Primary Completion	2027-12 (estimated)
Study Completion	2028-06 (estimated)
Updated on ClinicalTrials.gov	2026-04-17