Implant Placement Depth and Peri-Implant Tissue Outcomes

The primary aim of this randomized clinical trial is to evaluate the influence of subcrestal implant placement depth (-2 mm vs -4 mm) on peri-implant marginal bone level changes, including marginal bone loss and bone remodeling. Secondary outcomes include implant success, peri-implant probing depth (PPD), and bleeding on probing (BoP). Partially edentulous patients requiring fixed implant-supported prosthetic rehabilitation with two implants in posterior maxillary or mandibular regions will be included. Implants will be placed subcrestally at either -2 mm or -4 mm from the bone crest, following a submerged healing protocol. Allocation to insertion depth will be randomized. Marginal bone level changes will be assessed using standardized periapical radiographs at second-stage surgery, prosthesis placement, and at 1, 3, 6, and 12 months after functional loading. PPD and BoP will be recorded at the same time points.

NCT Number	NCT07535528
Lead Sponsor	University of Valencia
Conditions	Dental Implant Placement, Soft Tissue Management in Subcrestal Dental Implants, Marginal Bone Loss
Enrollment	80 participants
Start Date	2026-05-15
Primary Completion	2026-11-20 (estimated)
Study Completion	2027-07-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-13