Echocardiographic Assessment of the Effect of Impella on Biventricular Function

The objective of this prospective observational study is to evaluate the effects of Impella 5.5 on biventricular function in adult patients with end-stage heart failure requiring temporary mechanical circulatory support. The study will assess changes in left and right ventricular global longitudinal strain and myocardial work, as well as additional echocardiographic and hemodynamic parameters. Measurements will be obtained at baseline prior to Impella implantation, immediately after device initiation, and during postoperative follow-up up to Day 14. This study involves collection of echocardiographic imaging and clinical data, including additional imaging performed for research purposes.

NCT Number	NCT07534462
Lead Sponsor	University of Rochester Collaborators: Johnson & Johnson
Conditions	End-stage Heart Failure
Enrollment	24 participants
Start Date	2026-07-01
Primary Completion	2027-07-01 (estimated)
Study Completion	2027-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-01