Virtual Reality-Based Upper Limb Rehabilitation in Chronic Stroke

This randomized controlled study aims to evaluate the effectiveness of non-immersive virtual reality-based rehabilitation using the MindMotion™ GO system compared with conventional occupational therapy for improving upper limb motor function in individuals with chronic stroke. Stroke is a leading cause of long-term disability in adults worldwide, and barriers such as limited access to rehabilitation services, low motivation, and reduced adherence may hinder recovery in the chronic phase. Participants will be randomly assigned to either an experimental group receiving non-immersive virtual reality training or a control group receiving conventional occupational therapy according to standard clinical practice. Both groups will complete two rehabilitation sessions per week for eight weeks, with each session lasting approximately 40 minutes. The study will assess upper limb motor function, performance in activities of daily living, and quality of life. In addition, electroencephalography (EEG) will be used before and after the intervention to explore potential neuroplastic changes associated with rehabilitation. Outcome assessments will be conducted at baseline and at follow-up approximately three months after the initial evaluation. The results of this study may help determine whether non-immersive virtual reality is an effective and accessible tool to enhance rehabilitation outcomes in individuals with chronic stroke.

NCT Number	NCT07534124
Lead Sponsor	Universidad Complutense de Madrid
Conditions	Stroke, Rehabilitation, Upper Limb Paresis, Chronic Stroke Patient
Enrollment	26 participants
Start Date	2022-09-01
Primary Completion	2025-05-30 (estimated)
Study Completion	2025-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-23