Clinical Trial

Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung Cancer

Recruiting Phase 2
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Summary
The goal of this clinical trial is to understand whether Lactobacillus rhamnosus LR607 can enhance neoadjuvant chemoimmunotherapy for adult patients with non-small cell lung cancer. It will also evaluate the safety of LR607. The main questions it aims to answer include: Can LR607 improve the major pathological response of neoadjuvant chemoimmunotherapy? What is the relationship between LR607 combined with neoadjuvant chemoimmunotherapy and treatment-related adverse reactions? What changes occur in the gut microbiota composition at the species level and gut metabolites of subjects after LR607 treatment? Participants will: Take LR607 daily for 3 months Visit the hospital for check-ups and examinations every month Record their pathological response, tumor recurrence, and treatment-related adverse reactions
Trial Details
NCT Number NCT07534033
Lead Sponsor Zhujiang Hospital
Conditions NSCLC Diagnosed by Histology or Cytology, A Multidisciplinary Team Assessment Determined That the Patient Was a Suitable Candidate for Radical Surgical Resection, Overall Lung Function is Adequate for the Planned Lung Resection, AJCC is Classified as IB-IIIC
Enrollment 46 participants
Start Date 2025-12-06
Primary Completion 2026-12-23 (estimated)
Study Completion 2027-12-23 (estimated)
Updated on ClinicalTrials.gov 2026-04-16