VAP-Measured Lipid Subfractions and In-Stent Restenosis After PCI

This multicenter observational study investigates whether lipid and lipoprotein subfractions measured by Vertical Auto Profile (VAP) are associated with coronary in-stent restenosis after percutaneous coronary intervention (PCI). The study includes a retrospective cross-sectional component in patients with prior PCI who undergo repeat coronary angiography and a prospective follow-up component in patients undergoing index PCI. Serum samples obtained from routine clinical blood collection will be used for VAP testing without additional blood draws.

NCT Number	NCT07533656
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	In-Stent Restenosis, Coronary Artery Disease
Enrollment	3,600 participants
Start Date	2025-07-01
Primary Completion	2028-07-01 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-16