Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy

This randomized controlled trial aims to compare the analgesic efficacy of bilateral ultrasound-guided erector spinae plane block (ESPB) versus bilateral external oblique intercostal plane (EOI) block in patients undergoing open cholecystectomy. Patients will be randomly allocated into two groups to receive either ESPB or EOI block in addition to standard general anesthesia. The primary outcome is postoperative pain score assessed using the Numerical Rating Scale (NRS) at 2 hours after surgery. Secondary outcomes include intraoperative opioid consumption, postoperative nalbuphine requirements, time to first analgesic request, and hemodynamic changes. This study seeks to determine the more effective regional anesthesia technique for improving perioperative analgesia in open cholecystectomy.

NCT Number	NCT07533279
Lead Sponsor	Sohag University Collaborators: Cairo University
Conditions	Cholecystectomy, Postoperative Pain, Erector Spinae Plane Block, Regional Anesthesia
Enrollment	66 participants
Start Date	2026-06
Primary Completion	2026-06 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-04-16