Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium Vivax

This study is to conduct a clinical trial of tafenoquine combinations to compare the rates of therapeutic efficacy of dihydroartemisinin-piperaquine or artemether-lumefantrine with tafenoquine to chloroquine plus tafenoquine in preventing recurrence of Plasmodium vivax over a 6-month period in adult subjects with uncomplicated P. vivax infection living in Thailand.

NCT Number	NCT07533136
Lead Sponsor	Walter Reed Army Institute of Research (WRAIR)
Conditions	Uncomplicated P. Vivax Mono-infection
Enrollment	300 participants
Start Date	2026-05-01
Primary Completion	2028-10-31 (estimated)
Study Completion	2029-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-16