Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases

This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.

NCT Number	NCT07531732
Lead Sponsor	Assistance Publique - Hôpitaux de Paris Collaborators: Institut de psychologie, Université Paris Cité, Laboratoire Mémoire, Cerveau, Cognition
Conditions	Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease
Enrollment	34 participants
Start Date	2026-04
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-15