Clinical Trial

Perioperative Pharmacokinetics of Anesthetic Drugs and Complications in Overweight and Obese Patients

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Summary
This observational study aims to investigate the impact of body composition on the absorption, distribution, and metabolism of anesthetic drugs, as well as on the incidence of complications in overweight and obese patients. The primary research question is whether specific body composition parameters in this population influence drug pharmacokinetics and complication rates. By integrating pharmacokinetic parameters, adverse drug reactions (ADRs), and clinical complications, the study will analyze variations in sufentanil kinetics under different body composition conditions. Under the guidance of research personnel, participants will undergo non-invasive body composition assessment using the nBody S10 analyzer. Key metrics collected will include, but are not limited to, mineral content, muscle mass, lean body mass (LBM), total body weight, and body fat percentage (BFP).
Trial Details
NCT Number NCT07530848
Lead Sponsor Second Affiliated Hospital of Wenzhou Medical University
Conditions Obesity, Overweight
Enrollment 2,100 participants
Start Date 2026-04-10
Primary Completion 2028-04-30 (estimated)
Study Completion 2028-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-15