Clinical Trial

Adjacent Molar Outcomes After Third Molar Surgery With PRF or Collagen Sponge

Study acronym: PRFvsCOLL-3M
Completed
View on ClinicalTrials.gov →
Summary
This study aims to compare platelet-rich fibrin (PRF) and an absorbable collagen sponge in extraction sockets following impacted mandibular third molar removal in terms of postoperative clinical healing and periodontal and radiographic outcomes of adjacent second molars. Twenty-nine systemically healthy patients with bilaterally symmetrical impacted mandibular third molars will be included, and a total of 58 extraction sockets will be analyzed. Patients will be randomized using a sealed-envelope method into either the PRF group or the absorbable collagen sponge (Surgispon) group. In this split-mouth design, one side will receive the intervention and the contralateral side will serve as a control. Clinical and periodontal parameters will be recorded postoperatively, and radiographic healing will be evaluated using fractal analysis and lacunarity.
Trial Details
NCT Number NCT07530068
Lead Sponsor Gazi University
Conditions Impacted Mandibular Third Molar, Wound Healing, Postoperative Pain
Enrollment 29 participants
Start Date 2025-02-28
Primary Completion 2025-11-30 (estimated)
Study Completion 2026-02-28 (estimated)
Updated on ClinicalTrials.gov 2026-04-15