Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction

Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy. This prospective study evaluates the effectiveness of oral urea supplementation in patients with chronic SIAD and persistent hyponatremia despite fluid restriction.

NCT Number	NCT07528365
Lead Sponsor	University of Turin, Italy
Conditions	SIAD - Syndrome of Inappropriate Antidiuresis
Enrollment	20 participants
Start Date	2024-09-12
Primary Completion	2027-11 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-14