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Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis

Study acronym: EMPHASIS-2
StatusRecruiting
PhasePhase 3
Started2026-06-05
View on ClinicalTrials.gov ↗

Amendment history

2026-06-30
Study Status, Contacts/Locations v2
Recruitment opened
Start dateestimated 2026-05-01→confirmed 2026-06-05
Study sites1→3
2026-04-14
Study Status, Sponsor/Collaborators, Outcome Measures, IPDSharing v1
Primary endpoint(s) modified1 entry, revised
WasExcellent functional outcome
NowExcellent functional outcome (mRS of 0-1)
Secondary endpoints11 entries, revised
Good functional outcome (mRS of 0-2) Quality of life score (EQ-5D scale) Changes infrom baseline of National Institutes of Health Stroke Scale (NIHSS) scoresscore DiarrhoeaThe proportion of participants with diarrhoea, enteritis, and constipation SymptomaticThe proportion of participants with symptomatic intracranial hemorrhage AnyThe proportion of participants with any bleeding events AdverseThe events Seriousproportion of participants with adverse events The proportion of participants with serious adverse events
2026-04-08
Original filing
Beijing Tiantan Hospital
280 trials monitored
See 4 trials at risk
Stroke
3,268 trials monitored
See 122 trials at risk
The aim of this study is to assess the efficacy and safety of minocycline in improving functional outcome among patients with acute ischaemic stroke receiving intravenous thrombolysis.
Trial Details
NCT Number NCT07526987
Lead Sponsor Beijing Tiantan Hospital
Conditions Ischaemic Stroke
Enrollment 934 participants
Start Date 2026-06-05
Primary Completion 2028-12-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-01