Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)

COOLHEAD-2b is a multicentre, phase 2, prospective, randomised, controlled, open-label, blinded-endpoint trial evaluating the safety and efficacy of non-invasive convective head cooling as an adjunct to endovascular thrombectomy (EVT) in patients with acute anterior circulation ischaemic stroke. Head cooling is initiated as early as possible, including during inter-hospital transfer, and continued until one hour after reperfusion. The primary efficacy endpoint is final infarct volume at 24 hours.

NCT Number	NCT07526649
Lead Sponsor	Auckland City Hospital Collaborators: Neurological Foundation of New Zealand, Health New Zealand
Conditions	Stroke, Acute Ischemic Stroke, Brain Ischemia, Ischaemic Stroke, Thrombectomy, Endovascular Procedures, Reperfusion Injury, Cooling +1 more
Enrollment	182 participants
Start Date	2026-04-10
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-13