Effect of Recording Duration on Heart Rate Variability During taVNS

This study aims to evaluate how different heart rate variability (HRV) recording durations reflect autonomic nervous system responses during transcutaneous auricular vagus nerve stimulation (taVNS) in healthy adults. In a randomized, sham-controlled crossover design, participants will attend two separate sessions and receive both active taVNS and sham stimulation in randomized order. During each session, a continuous 10-minute HRV recording will be obtained, and 1-minute, 5-minute, and 10-minute analysis windows will be compared. Blood pressure and pulse will also be measured before and after stimulation. The study will investigate whether shorter or longer HRV recording durations provide results comparable to the standard 5-minute recording and which duration most reliably detects autonomic changes during taVNS.

NCT Number	NCT07526415
Lead Sponsor	Sinop University
Conditions	Healthy Volunteers
Enrollment	40 participants
Start Date	2026-05-01
Primary Completion	2026-08-31 (estimated)
Study Completion	2026-09-15 (estimated)
Updated on ClinicalTrials.gov	2026-04-16