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Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery

StatusNot Yet Recruiting
PhasePhase 4
Started
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Record History

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  1. Primary endpoint(s) modified
    • Secondary endpoint revised
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may reduce CPSP in patients after spinal surgery.
Trial Details
NCT Number NCT07525999
Lead Sponsor Peking University First Hospital
Conditions
(from sponsor)		 Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine, Postoperative Analgesia
Related terms Pain
Enrollment 274 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov