Effects of PRF and i-PRF on Clinical and Biochemical Parameters in Non-Surgical Periodontal Therapy

The goal of this clinical trial is to learn if adding platelet-rich fibrin (PRF) or injectable platelet-rich fibrin (i-PRF), obtained from the participant's own blood, to standard non-surgical periodontal treatment helps improve gum health in individuals with periodontitis. It will also assess how these applications affect inflammation and bone-related markers in the gum fluid. The main questions it aims to answer are : * Does the application of PRF or i-PRF improve clinical periodontal healing compared to standard treatment alone? * Do these applications influence the levels of inflammatory and bone metabolism-related biomarkers in gingival crevicular fluid? Researchers will compare patients receiving PRF or i-PRF in addition to standard periodontal treatment with those receiving standard treatment alone. In addition, the findings obtained from individuals with periodontal disease will be compared with data from periodontally healthy individuals. Participants will: * Receive standard periodontal treatment (scaling and root planing) * Receive PRF or i-PRF depending on their assigned group * Visit the clinic before treatment and at 2, 4, and 6 weeks after treatment for checkups

NCT Number	NCT07525531
Lead Sponsor	Ondokuz Mayıs University
Conditions	Periodontitis
Enrollment	56 participants
Start Date	2024-04-20
Primary Completion	2025-08-05 (estimated)
Study Completion	2025-12-25 (estimated)
Updated on ClinicalTrials.gov	2026-04-15