Clinical Trial

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

Recruiting Phase 3
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Summary
The goal of this clinical trial is to evaluate whether antenatal magnesium sulphate reduces the risk of cerebral palsy in infants born to women at high risk of preterm birth. It will also assess the safety of magnesium sulfate for both the mother and the neonate. The main question it aims to answer is whether magnesium sulphate given before anticipated preterm delivery decreases the incidence of cerebral palsy without causing significant maternal or neonatal adverse effects. Researchers will compare magnesium sulphate with a placebo in women at high risk of preterm birth between 32 and 35 weeks of gestation. Participants will be randomly assigned to receive either intravenous magnesium sulphate or a placebo before delivery, and maternal and neonatal outcomes will be followed after birth, including neurodevelopmental assessment of the infant.
Trial Details
NCT Number NCT07524972
Lead Sponsor Cairo University
Collaborators: Suez Canal University
Conditions Cerebral Palsy, Magnesium Sulfate Overdose
Enrollment 138 participants
Start Date 2026-05-01
Primary Completion 2028-04-30 (estimated)
Study Completion 2028-05-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-13