Local Radiotherapy for Urinary Bladder Cancer in Patients Not Eligible for Curative Treatment

The goal of this clinical trial is to improve the quality of life and prolong survival in bladder cancer patients unfit for curative treatment. The trial will compare the survival and symptoms of patients randomized to either local radiotherapy in addition to standard of care or standard of care alone. Using modern radiotherapy techniques, including hypofractionation and image-guided treatment adaptation, the aim is to deliver a well-tolerated, time-efficient, and effective treatment strategy for these patients. The trial collaborates with two ongoing exploratory biomarker studies collecting and analyzing potential biomarkers in urothelial bladder cancer. The hope is to provide biomarkers for prognosis and treatment response which is essential to ensure bladder cancer patients individualized treatment in the future, like those with breast and prostate cancer.

NCT Number	NCT07524426
Lead Sponsor	Umeå University Collaborators: Västerbotten County Council, Sweden
Conditions	Bladder Cancer (BC)
Enrollment	248 participants
Start Date	2026-06-03
Primary Completion	2032-06 (estimated)
Study Completion	2034-06 (estimated)
Updated on ClinicalTrials.gov	2026-06-09