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Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid Tumors

Study acronym: SELECT-2CAR
StatusRecruiting
PhasePhase 1/2
Started2026-03-02
View on ClinicalTrials.gov ↗
This is a multicenter, open-label, Phase 1/2 master protocol evaluating autologous dual-target CAR-T cell therapy in adults with advanced solid cancers. After central biomarker screening, each participant is assigned the best-matched dual-target construct from a predefined target-pair library. The trial is designed to test whether biomarkerguided dual targeting can improve tumor control, reduce antigenescape risk, and preserve safety in solid tumors.
Trial Details
NCT Number NCT07523529
Lead Sponsor Beijing Biotech
Conditions Advanced Unresectable, Metastatic
Enrollment 72 participants
Start Date 2026-03-02
Primary Completion 2027-04-14 (estimated)
Study Completion 2028-03-17 (estimated)
Updated on ClinicalTrials.gov 2026-04-13