Clinical Trial

A Digital Cognitive Intervention for Intrusive Memories After Trauma

Not Yet Recruiting
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Summary
Intrusive traumatic memories frequently trigger severe distress and psychological disorders like PTSD. Traditional therapies require explicit trauma recall, which often causes severe patient distress and leads to treatment avoidance. To address this, our study introduces a novel, less aversive intervention combining unconscious visual processing with bilateral eye movement to mitigate these intrusive memories. Utilizing a randomized, three-arm design (comparing standardized trauma-related images, patient-provided images, and neutral images, all paired with bilateral eye movements), we plan to recruit participants who have experienced severe trauma and report ≥ 5 intrusive memories weekly, targeting a final sample of 40 patients per arm. The primary outcome is the frequency of intrusive memories. Secondary and additional outcomes include PTSD severity (CAPS-5, PCL-5, IES), depression, anxiety, borderline symptoms, functional improvements, subjective intervention distress, and dropout rates.
Trial Details
NCT Number NCT07523360
Lead Sponsor Zhu Zijian
Conditions Post-Traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Enrollment 123 participants
Start Date 2026-04-10
Primary Completion 2028-02-10 (estimated)
Study Completion 2028-05-10 (estimated)
Updated on ClinicalTrials.gov 2026-04-13