Validation of Presence-IP1.0 for Detection of Consciousness Using Reduced-Montage TMS-EEG

This study aims to validate a novel real-time algorithm (Presence-IP1.0) designed to detect consciousness from TMS-evoked EEG responses using a reduced electrode montage. Thirty healthy adult participants will undergo TMS-EEG recordings during wakefulness and sleep. The algorithm's ability to differentiate conscious from unconscious states will be evaluated against behavioral and physiological state classification. The goal is to determine whether Presence-IP1.0 achieves clinically useful accuracy for detecting consciousness using a portable, reduced-channel system.

NCT Number	NCT07523191
Lead Sponsor	University of Wisconsin, Madison Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Intrinsic Powers, Inc
Conditions	Sleep
Enrollment	30 participants
Start Date	2026-03-18
Primary Completion	2027-04 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-04-13