Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder

This study will look at how a new medication (dextromethorphan and bupropion taken together in one pill) affects the brain in people with depression. All participants will take the medication for two weeks and have brain scans done. Since people with depression often feel reduced enjoyment in day-to-day activities, our goal is to learn if this treatment can change brain activities in ways that could help improve mood and enjoyment in life.

NCT Number	NCT07523048
Lead Sponsor	Roger McIntyre Collaborators: Axsome Therapeutics, Inc.
Conditions	Major Depressive Disorder (MDD)
Enrollment	30 participants
Start Date	2025-11-21
Primary Completion	2026-07 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-13