Clinical Trial

Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups

Study acronym: GONACLO
Enrolling by Invitation Phase 4
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Summary
Men enrolled in the study are assigned to each APHRODITE group. Group 2,3,4 are treated with either gonadotropin preparations or clompihene-citrate (except group 4). The type of the treatment (gonadotropin vs clomiphene) is randomized. After treatment, hormonal measurements, spermiogram and DNA fragmentation tests are repeated, allowing for analysis of the outcome.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-04-04.
Trial Details
NCT Number NCT07523022
Lead Sponsor Szeged University
Conditions Male Infertility
Enrollment 500 participants
Start Date 2024-09-01
Primary Completion 2026-09-01 (estimated)
Study Completion 2026-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-16