Clinical Trial

Rifaximin Treatment in Bloating Predominant Functional Bowel Disorders

Not Yet Recruiting Phase 3
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Summary
This randomized, double-blind, placebo-controlled trial will evaluate whether a 14-day course of rifaximin improves bloating in adult patients with Rome IV functional bowel disorders in whom bloating is the predominant symptom. Eligible participants with irritable bowel syndrome, functional constipation, or functional abdominal bloating/distension and bothersome bloating despite adequate bowel movement management will be assigned in a 1:1 ratio to rifaximin 550 mg three times daily or matching placebo for 2 weeks. The primary endpoint is the proportion of participants with bloating response, defined as at least a 1-point reduction from baseline in a 7-point Likert bloating score at the end of treatment.
Trial Details
NCT Number NCT07522255
Lead Sponsor Mahidol University
Conditions Bloating, Rifaximin, Functional Bowel Disorder, Irritable Bowel Syndrome, Constipation
Enrollment 78 participants
Start Date 2026-04
Primary Completion 2027-10 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-04-13