Non-Invasive Ventilation Interfaces and Nasal Pressure Injury in Preterm Infants

The goal of this randomized controlled clinical trial is to learn whether different non-invasive ventilation interfaces can prevent medical device-related nasal pressure injury in preterm infants receiving respiratory support in a neonatal intensive care unit. The main questions it aims to answer are: * Do different non-invasive ventilation interfaces affect how often nasal pressure injury develops? * Do these interfaces affect the severity of nasal pressure injury and the condition of the nasal skin? Researchers will compare three types of non-invasive ventilation interfaces (binasal prong, nasal cannula, and nasal mask) to see if one method is more effective in reducing nasal pressure injury. Participants will: * Be randomly assigned to one of three groups (binasal prong, nasal cannula, or nasal mask) * Receive non-invasive ventilation support using the assigned interface for at least 4 days * Have their nasal skin assessed every 12 hours for 96 hours using standardized scales * Continue to receive routine care in the neonatal intensive care unit

NCT Number	NCT07521410
Lead Sponsor	Istanbul University - Cerrahpasa
Conditions	Medical Device-Related Pressure Injury, Prematurity
Enrollment	75 participants
Start Date	2026-04-20
Primary Completion	2026-04-24 (estimated)
Study Completion	2026-10-24 (estimated)
Updated on ClinicalTrials.gov	2026-04-16