Clinical Trial

A Study to Learn About the Medicine Called PF-08653944 in People With and Without Reduced Liver Function

Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
This study is being done to learn more about an investigational medicine called PF-08653944. The goal is to understand how the body handles the medicine and to check its safety after a single dose. The study includes adults with normal liver function and adults who have mild, moderate, or severe liver problems. By comparing these groups, researchers want to understand whether liver function changes how the medicine behaves in the body. People who join the study will receive one injection of the study medicine. They will stay at the study clinic for a short time and return for follow-up visits so doctors can do blood tests, physical exams, and safety checks. This study is not expected to provide direct medical benefit to participants. The information collected will help researchers develop future treatments and understand how this medicine may be used safely in people with liver disease.
Protocol Amendment History 2 changes
critical Recruitment opened 2026-04-24
notable Trial sites expanded: 0 -> 3 locations 2026-04-24
Trial Details
NCT Number NCT07519135
Lead Sponsor Pfizer
Conditions Healthy
Enrollment 26 participants
Start Date 2026-04-15
Primary Completion 2027-07-09 (estimated)
Study Completion 2027-07-09 (estimated)
Updated on ClinicalTrials.gov 2026-04-23