Gut Microbiome in Patients With Post-infectious Irritable Bowel Syndrome

Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS). The study will compare microbiome composition and function between PI-IBS patients and two control groups (post-infectious subjects without irritable bowel syndrome -IBS- and healthy controls), with the goal of identifying reproducible microbial signatures and target taxa associated with disease and symptom severity.

NCT Number	NCT07517029
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions	IBS - Irritable Bowel Syndrome, Post Infection Syndrome
Enrollment	315 participants
Start Date	2026-04-08
Primary Completion	2028-10 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-13