Vitamin D and Immune Response in Pulmonary Tuberculosis With and Without Chronic Pulmonary Aspergillosis

The goal of the study is to determine whether vitamin D levels are associated with cytokine profiles in patients with pulmonary tuberculosis, including those with chronic pulmonary aspergillosis. The main questions it aims to answer are: * Is there an association between serum 25-hydroxyvitamin D levels and pro- and anti-inflammatory cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α) in patients with active pulmonary tuberculosis? * Does this association differ in patients with pulmonary tuberculosis complicated by chronic pulmonary aspergillosis compared to those without CPA and to healthy individuals? Researchers will compare: * Active pulmonary tuberculosis (PTB) patients * PTB patients with chronic pulmonary aspergillosis (PTB-CPA) * Healthy control subjects To see if differences in vitamin D levels are associated with variations in cytokine responses among these groups. Participants will: * Provide blood samples for measurement of serum 25-hydroxyvitamin D * Undergo laboratory assessment of cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α) using ELISA * Be classified into study groups based on clinical diagnosis (PTB, PTB-CPA, or healthy controls)

NCT Number	NCT07516158
Lead Sponsor	Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Conditions	Pulmonary Tuberculoses, Chronic Pulmonary Aspergillosis, Healthy Participants
Enrollment	300 participants
Start Date	2015-01-01
Primary Completion	2027-10-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-13