Weight Loss Via Intelligent Guidance in Patients With Coronary Heart Disease and Obesity: a Randomized Clinical Trial

Coronary Heart Disease (CHD) is an ischemic heart disease caused by coronary atherosclerosis, and it is the leading cause of death from cardiovascular diseases worldwide. Weight loss in obese patients can significantly improve metabolic indicators such as dyslipidemia and insulin resistance; therefore, weight loss may become a target for improving the prognosis of obese patients with coronary heart disease. This study is a multicenter, randomized controlled clinical trial aimed at evaluating the effect of software-based healthy weight loss guidance (personalized diet + exercise intervention) in obese patients with coronary heart disease. It is expected that 136 patients will be enrolled in hospitals including Guangdong Provincial People's Hospital, with a total study duration of 1 year.

NCT Number	NCT07514611
Lead Sponsor	Guangdong Provincial People's Hospital Collaborators: Yuebei People's Hospital, Guangzhou Red Cross Hospital, Zhongshan Hospital Of Traditional Chinese Medicine, Shenzhen Nanshan Institute of Chronic Disease Control, Dongguan Binhaiwan Central Hospital, The Eighth People's Hospital of Nanning, People's Hospital of Xinjiang Uygur Autonomous Region, Nanyang Central Hospital, The First People's Hospital of Yunnan, The First People's Hospital of Nanning
Conditions	CHD, Overweight or Obese
Enrollment	140 participants
Start Date	2026-04-18
Primary Completion	2028-07-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-12